Tuberculosis Treatment Interruptions—Ivanovo Oblast, Russian Federation, 1999
2001; American Medical Association; Volume: 285; Issue: 15 Linguagem: Inglês
10.1001/jama.285.15.1953
ISSN1538-3598
Tópico(s)Tuberculosis Research and Epidemiology
ResumoIn 1995 WHO implemented a pilot TB control project in the Ivanovo oblast of the Russian Federation. The project was based on five elements of WHO’s directly observed treatment short-course strategy for controlling TB and in most settings the strategy has resulted in cure rate of 85% or higher. However little improvement was noted in Ivanovo after the implementation of the strategy. Although 17% of these poor outcomes were attributed to primary multidrug-resistant TB other factors like treatment delay and interruption were not quantified. Thus CDC reviewed the TB treatment records for all newly diagnosed never-treated pulmonary TB patients registered in Ivanovo from April through June 1999. The aim was to determine the extent of treatment interruption as a potential cause of poor outcomes among TB patients. This report summarizes the results of the analysis and indicates that approximately one-fourth of highly infectious TB patients interrupted treatment for 2-8 weeks and nearly one-fourth of them interrupted treatment for more than 8 weeks. Based on these results TB project staff have increased efforts to reduce treatment interruption through use of incentives.
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