Carrier-mediated blood-brain barrier transport of short-chain monocarboxylic organic acids
1973; American Physiological Society; Volume: 224; Issue: 6 Linguagem: Inglês
10.1152/ajplegacy.1973.224.6.1450
ISSN2163-5773
Autores Tópico(s)Advanced Chemical Sensor Technologies
ResumoARTICLESCarrier-mediated blood-brain barrier transport of short-chain monocarboxylic organic acidsWH OldendorfWH OldendorfPublished Online:01 Jun 1973https://doi.org/10.1152/ajplegacy.1973.224.6.1450MoreSectionsPDF (864 KB)Download PDF ToolsExport citationAdd to favoritesGet permissionsTrack citations ShareShare onFacebookTwitterLinkedInWeChat Previous Back to Top Next Download PDF FiguresReferencesRelatedInformation Cited ByThe importance of gut-brain axis and use of probiotics as a treatment strategy for multiple sclerosisMultiple Sclerosis and Related Disorders, Vol. 71Butyrate ameliorates quinolinic acid–induced cognitive decline in obesity models15 February 2023 | Journal of Clinical Investigation, Vol. 133, No. 4Gut microbiota-derived metabolites and their importance in neurological disorders18 November 2022 | Molecular Biology Reports, Vol. 50, No. 2Peripheral Regulation of Central Brain-Derived Neurotrophic Factor Expression through the Vagus Nerve10 February 2023 | 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Molecular Basis of Disease, Vol. 1852, No. 5High Caloric Diets in Amyotrophic Lateral ScleroisMetabolic Dysfunctions in Epilepsy and Novel Metabolic Treatment ApproachesTreatment of Eye Infections8 April 2014Pathways for Small Molecule Delivery to the Central Nervous System across the Blood-Brain Barrier16 June 2014 | Perspectives in Medicinal Chemistry, Vol. 6Pyruvate Administration Reduces Recurrent/Moderate Hypoglycemia-Induced Cortical Neuron Death in Diabetic Rats22 November 2013 | PLoS ONE, Vol. 8, No. 11Metabolic products of [2- 13 C]ethanol in the rat brain after chronic ethanol exposure23 September 2013 | Journal of Neurochemistry, Vol. 127, No. 3Oxidation of ethanol in the rat brain and effects associated with chronic ethanol exposure12 August 2013 | Proceedings of the National Academy of Sciences, Vol. 110, No. 35Neuroprotective effects of alpha-ketoglutarate and ethyl pyruvate against motor dysfunction and oxidative changes caused by repeated 1-methyl-4-phenyl-1,2,3,6 tetrahydropyridine exposure in mice2 July 2013 | Human & Experimental Toxicology, Vol. 32, No. 7Computer modeling of blood brain barrier permeability for physiologically active compounds2 June 2013 | Biochemistry (Moscow) Supplement Series B: Biomedical Chemistry, Vol. 7, No. 2Modulation of Inflammatory Cytokines and Mitogen-activated Protein Kinases by Acetate in Primary Astrocytes12 December 2012 | Journal of Neuroimmune Pharmacology, Vol. 8, No. 1Computational Prediction of CNS Drug Exposure Based on a Novel In Vivo Dataset29 June 2012 | Pharmaceutical Research, Vol. 29, No. 11Quantitative assessment of dynamic PET imaging data in cancer imagingMagnetic Resonance Imaging, Vol. 30, No. 9Physiologie des vaisseaux rétiniensEMC - 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Puchowicz, Kui Xu, Xiaoyan Sun, Andre Ivy, Doug Emancipator, and Joseph C. LaManna1 June 2007 | American Journal of Physiology-Endocrinology and Metabolism, Vol. 292, No. 6Brain pyruvate recycling and peripheral metabolism: an NMR analysis ex vivo of acetate and glucose metabolism in the ratJournal of Neurochemistry, Vol. 101, No. 5Lack of utility of arteriojugular venous differences of lactate as a reliable indicator of increased brain anaerobic metabolism in traumatic brain injuryJournal of Neurosurgery, Vol. 106, No. 4Synaptic Plasma Membrane Na+, K+-ATPase Activity is Significantly Reduced by the α-Keto Acids Accumulating in Maple Syrup Urine Disease in Rat Cerebral Cortex13 February 2007 | Metabolic Brain Disease, Vol. 22, No. 1Neuroprotective Mechanisms: Oxidative Stress as a Target for Neuroprotective Therapies in Alzheimer's and Parkinson's Disease1 January 20074.5 Coupling of Brain Function to Metabolism: Evaluation of Energy Requirements1 January 20072.1 The Support of Energy Metabolism in the Central Nervous System with Substrates Other than Glucose1 January 2007Commentary on: The aetiology of neurological complications of organic acidaemias—a role for the blood–brain barrier. Kölker S, Sauer SW, Surtees RAH, Leonard JV10 November 2006 | Journal of Inherited Metabolic Disease, Vol. 29, No. 6Inhibition of the Electron Transport Chain and Creatine Kinase Activity by Ethylmalonic Acid in Human Skeletal Muscle28 April 2006 | Metabolic Brain Disease, Vol. 21, No. 1Effect of In Vivo Administration of Ethylmalonic Acid on Energy Metabolism in Rat Tissues28 April 2006 | Metabolic Brain Disease, Vol. 21, No. 1Pyruvate Administered After Severe Hypoglycemia Reduces Neuronal Death and Cognitive ImpairmentDiabetes, Vol. 54, No. 5Protection by exogenous pyruvate through a mechanism related to monocarboxylate transporters against cell death induced by hydrogen peroxide in cultured rat cortical neuronsJournal of Neurochemistry, Vol. 93, No. 1Activation of astrocytes in brain of conscious rats during acoustic stimulation: acetate utilization in working brainJournal of Neurochemistry, Vol. 92, No. 4Small molecular drug transfer across the blood-brain barrier via carrier-mediated transport systemsNeuroRX, Vol. 2, No. 1Inhibition of energy metabolism in cerebral cortex of young rats by the medium-chain fatty acids accumulating in MCAD deficiencyBrain Research, Vol. 1030, No. 1Analysis of neuronal and glial functions in cerebral ischaemia: an approach with nuclear medicineInternational Congress Series, Vol. 1264Development of the Blood-Brain BarrierNew Aspects of the Blood–Brain Barrier Transporters; Its Physiological Roles in the Central Nervous SystemBiological & Pharmaceutical Bulletin, Vol. 27, No. 10The Physiological Function of the Blood-Brain Barrier Transporters as the CNS Supporting and Protecting SystemYAKUGAKU ZASSHI, Vol. 124, No. 11Inhibition of brain energy metabolism by the α-keto acids accumulating in maple syrup urine diseaseBiochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, Vol. 1639, No. 3Molecular Features, Regulation, and Function of Monocarboxylate Transporters: Implications for Drug DeliveryJournal of Pharmaceutical Sciences, Vol. 92, No. 8Energy Contribution of Octanoate to Intact Rat Brain Metabolism Measured by 13 C Nuclear Magnetic Resonance Spectroscopy2 July 2003 | The Journal of Neuroscience, Vol. 23, No. 13Deficiency in short-chain fatty acid β-oxidation affects theta oscillations during sleep8 June 2003 | Nature Genetics, Vol. 34, No. 3Rat Organic Anion Transporter 3 (rOAT3) Is Responsible for Brain-to-Blood Efflux of Homovanillic Acid at the Abluminal Membrane of Brain Capillary Endothelial CellsJournal of Cerebral Blood Flow & Metabolism, Vol. 55Rat Organic Anion Transporter 3 (rOAT3) is Responsible for Brain-to-Blood Efflux of Homovanillic Acid at the Abluminal Membrane of Brain Capillary Endothelial Cells31 August 2016 | Journal of Cerebral Blood Flow & Metabolism, Vol. 23, No. 4Radiopaques15 January 2003Coupling and Compartmentation of Cerebral Blood Flow and MetabolismFunctional expression and localization of P-glycoprotein at the blood brain barrier22 May 2002 | Microscopy Research and Technique, Vol. 57, No. 5In vitro uptake of [1-14C]Octanoate in brain slices of rats: basic studies for assessing [1-11C]Octanoate as a PET tracer of glial functionsNuclear Medicine and Biology, Vol. 29, No. 3Local uptake of14C-labeled acetate and butyrate in rat brain in vivo during spreading cortical depression1 January 2001 | Journal of Neuroscience Research, Vol. 66, No. 5Glycolysis in Neurons, Not Astrocytes, Delays Oxidative Metabolism of Human Visual Cortex during Sustained Checkerboard Stimulation in vivo31 August 2016 | Journal of Cerebral Blood Flow & Metabolism, Vol. 21, No. 12Measurement of β-hydroxybutyrate in acute hyperketonemia in human brain7 July 2008 | Journal of Neurochemistry, Vol. 79, No. 3Inhibition of in vitro CO2 production and lipid synthesis by 2-hydroxybutyric acid in rat brainBrazilian Journal of Medical and Biological Research, Vol. 34, No. 5Transporter-Mediated Permeation of Drugs Across the Blood–Brain BarrierJournal of Pharmaceutical Sciences, Vol. 89, No. 11Inhibition of energy productionin vitro by glutaric acid in cerebral cortex of young ratsMetabolic Brain Disease, Vol. 15, No. 2Dopamine toxicity in neuroblastoma cells: role of glutathione depletion by l-BSO and apoptosisBrain Research, Vol. 858, No. 1Preliminary evaluation of [1-11C]octanoate as a PET tracer for studying cerebral ischemia: A PET study in rat and canine models of focal cerebral ischemiaAnnals of Nuclear Medicine, Vol. 14, No. 1Pyruvate and lactate protect striatal neurons against N-methyl- d -aspartate-induced neurotoxicity24 December 2001 | European Journal of Neuroscience, Vol. 11, No. 9Vector-mediated drug delivery to the brainAdvanced Drug Delivery Reviews, Vol. 36, No. 2-3Maturational changes in cerebral lactate and acid clearance following ischemia measured in vivo using magnetic resonance spectroscopy and microdialysisDevelopmental Brain Research, Vol. 113, No. 1-22-Oxoacids Regulate Kynurenic Acid Production in the Rat Brain1 May 2002 | Journal of Neurochemistry, Vol. 72, No. 2Reduced Counterregulation during Hypoglycemia with Raised Circulating Nonglucose Lipid Substrates: Evidence for Regional Differences in Metabolic Capacity in the Human Brain?The Journal of Clinical Endocrinology & Metabolism, Vol. 83, No. 8Preferential Utilization of Acetate by Astrocytes Is Attributable to Transport15 July 1998 | The Journal of Neuroscience, Vol. 18, No. 14Direct Evidence that Lactate is an Obligatory Aerobic Energy Substrate for Functional Recovery Posthypoxia in VitroPyruvate Protects Neurons against Hydrogen Peroxide-Induced Toxicity1 December 1997 | The Journal of Neuroscience, Vol. 17, No. 23Transport of α-Ketoisocaproate in Neuroblastoma NB-2a CellsBiochemical and Biophysical Research Communications, Vol. 237, No. 1Age-related changes in the blood-brain barrierExperimental Gerontology, Vol. 32, No. 4-5Aluminum citrate is transported from brain into blood via the monocar☐ylic acid transporter located at the blood-brain barrierToxicology, Vol. 120, No. 2Role of adenosine in the ethanol-induced potentiation of the effects of general anesthetics in ratsEuropean Journal of Pharmacology, Vol. 325, No. 2-3Transport und Entgiftung: Grundlagen, Ansätze und Perspektiven für die Erforschung der Blut-Hirn-SchrankeAngewandte Chemie, Vol. 109, No. 1-2Permeability of the Blood-Brain Barrier to Circulating Free Fatty AcidsModeling the Route of Administration-Based Enhancement in the Brain Delivery of EAB 515, Studied by Microdialysis20 October 2008 | Journal of Drug Targeting, Vol. 4, No. 5Uptake of radioactive octanoate in astrocytoma cells: Basic studies for application of [11C]octanoate as a PET tracerAnnals of Nuclear Medicine, Vol. 10, No. 4Transport of carnitine in RBE4 cells - an in vitro model of blood-brain barrier8 January 1999 | Neuroscience Research Communications, Vol. 19, No. 3[1-11C]Octanoate as a potential PET tracer for studying glial functions: PET evaluation in rats and catsNuclear Medicine and Biology, Vol. 23, No. 8Evaluation of the brain uptake properties of [1-11C]labeled hexanoate in anesthetized cats by means of positron emission tomographyAnnals of Nuclear Medicine, Vol. 10, No. 3A brain uptake study of [1-11C]hexanoate in the mouse: The effect of hypoxia, starvation and substrate competitionAnnals of Nuclear Medicine, Vol. 10, No. 2Drug delivery through the blood-brain barrierAdvanced Drug Delivery Reviews, Vol. 19, No. 3Non-Anticoagulant Actions of Glycosaminoglycans (GAGs)Mechanism of valproic acid uptake by isolated rat brain microvesselsEpilepsy Research, Vol. 22, No. 2Brain uptake and metabolism of [1-11C]octanoate in rats: Pharmacokinetic basis for its application as a radiopharmaceutical for studying brain fatty acid metabolismAnnals of Nuclear Medicine, Vol. 9, No. 3Transport of small molecules through the blood-brain barrier: biology and methodologyAdvanced Drug Delivery Reviews, Vol. 15, No. 1-3Synthesis and preliminary evaluation of [1-11C]hexanoate as a PET tracer of fatty acid metabolismAnnals of Nuclear Medicine, Vol. 9, No. 1The role of acetate as a potential mediator of the effects of ethanol in the brainNeuroscience Letters, Vol. 186, No. 2-3Animal models for studying transport across the blood-brain barrierJournal of Neuroscience Methods, Vol. 56, No. 1Drug delivery via active transport at the blood-brain barrier: II. Investigation of monocarboxylic acid transport in vitroInternational Journal of Pharmaceutics, Vol. 108, No. 38-[18F]fluorooctanoic acid and its β-substituted derivatives as potential agents for cerebral fatty acid studies: Synthesis and biodistributionNuclear Medicine and Biology, Vol. 21, No. 6Diabetic chronic hyperglycemia and cerebral pH recovery following global ischemia in dogs.Stroke, Vol. 25, No. 7Acetate-Mediated Effects of EthanolAlcoholism: Clinical and Experimental Research, Vol. 18, No. 1Metabolism of triacetin-derived acetate in dogsThe American Journal of Clinical Nutrition, Vol. 58, No. 6Elevation of 2-methylcitric acid I and II levels in serum, urine, and cerebrospinal fluid of patients with cobalamin deficiencyMetabolism, Vol. 42, No. 8The blood‐brain barrier: Cellular basis1 July 1993 | Journal of Inherited Metabolic Disease, Vol. 16, No. 4Physiology and pathophysiology of organic acids in cerebrospinal fluid1 July 1993 | Journal of Inherited Metabolic Disease, Vol. 16, No. 4Regional blood-brain lactate influxBrain Research, Vol. 614, No. 1-2Physiological Stimulation Increases Nonoxidative Glucose Metabolism in the Brain of the Freely Moving RatJournal of Neurochemistry, Vol. 60, No. 4Glucose and ketone body utilization by the brain of neonatal ratsProgress in Neurobiology, Vol. 40, No. 2History and Basic ConceptsActions of ethanol and acetate on rat cortical neurons: Ethanol/adenosine interactionsAlcohol, Vol. 9, No. 6Phosphate transport by capillaries of the blood-brain barrier.Journal of Biological Chemistry, Vol. 267, No. 31Electrophysiological actions of acetate, a metabolite of ethanol, on hippocampal dentate granule neurons: interactions with adenosineBrain Research, Vol. 588, No. 1Octanoic Acid Produces Accumulation of Monoamine Acidic Metabolites in the Brain: Interaction with Organic Anion Transport at the Choroid PlexusJournal of Neurochemistry, Vol. 58, No. 4Uptake and hydrolysis of glycylglutamine at the blood-brain barrierMetabolism, Vol. 41, No. 2Regional Blood to Brain Transport of LactateLocalized magnetic resonance spectroscopy measurement of brain lactate during intravenous lactate infusion in healthy volunteersLife Sciences, Vol. 51, No. 12Dietary Cholesterol and the Origin of Cholesterol in the Brain of Developing RatsThe Journal of Nutrition, Vol. 121, No. 9Autoradiographic Measurement of Cerebral Lactate Transport Rate Constants in Normal and Activated Conditions29 June 2016 | Journal of Cerebral Blood Flow & Metabolism, Vol. 11, No. 4Fatty Acid Oxidation and Ketogenesis by Astrocytes in Primary CultureJournal of Neurochemistry, Vol. 56, No. 4The origin of free brain malonateNeurochemical Research, Vol. 16, No. 2Blood-Brain Barrier Transport of Glucose, Free Fatty Acids, and Ketone BodiesMolecular Anatomy of the Blood-Brain Barrier as Defined by ImmunocytochemistryBlood—Brain Barrier: Transport Studies in Isolated Brain Capillaries and in Cultured Brain Endothelial CellsThe Effect of Combined Hypoxemia and Cephalic Hypotension on Fetal Cerebral Blood Flow and Metabolism28 June 2016 | Journal of Cerebral Blood Flow & Metabolism, Vol. 11, No. 1Triacetin: A Potential Parenteral Nutrient2 July 2016 | Journal of Parenteral and Enteral Nutrition, Vol. 15, No. 1Metabolic and Neurologic Effects of an Intravenous Medium-Chain Triglyceride Emulsion2 July 2016 | Journal of Parenteral and Enteral Nutrition, Vol. 15, No. 1Drug Disposition in the Mammalian Eye and Brain: A Comparison of Mechanisms22 September 2008 | Drug Metabolism Reviews, Vol. 23, No. 1-2l-Carnitine prevents mitochondrial damage
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