New developments for antibody-drug conjugate-based therapeutic approaches
2016; Elsevier BV; Volume: 40; Linguagem: Inglês
10.1016/j.coi.2016.02.008
ISSN1879-0372
AutoresBart ECG de Goeij, John M. Lambert,
Tópico(s)Cancer Treatment and Pharmacology
ResumoThe clinical success of Adcetris(®) (brentuximab vedotin) and Kadcyla(®) (ado-trastuzumab emtansine) has sparked clinical development of novel ADCs. These powerful anti-cancer agents are designed to allow specific targeting of highly potent cytotoxic agents to tumor cells while sparing healthy tissues. Despite the use of tumor-specific antibodies, the emerging clinical data with ADCs indicates that adverse effects frequently occur before ADCs have reached their optimal therapeutic dose, resulting in a relatively narrow therapeutic window. This review summarizes the therapeutic window of ADCs currently in clinical development, along with some strategies that may help to widen the window.
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