Synthetic Strategies toward Natural Products Containing Contiguous Stereogenic Quaternary Carbon Atoms
2016; Wiley; Volume: 55; Issue: 13 Linguagem: Inglês
10.1002/anie.201507549
ISSN1521-3773
AutoresMartin Büschleb, Stéphane Dorich, Stephen Hanessian, Daniel J. Tao, Kyle B. Schenthal, Larry E. Overman,
Tópico(s)Chemical synthesis and alkaloids
ResumoAbstract Strategies for the total synthesis of complex natural products that contain two or more contiguous stereogenic quaternary carbon atoms in their intricate structures are reviewed with 12 representative examples. Emphasis has been put on methods to create quaternary carbon stereocenters, including syntheses of the same natural product by different groups, thereby showcasing the diversity of thought and individual creativity. A compendium of selected natural products containing two or more contiguous stereogenic quaternary carbon atoms and key reactions in their total or partial syntheses is provided in the Supporting Information.
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