Portal de Periódicos da CAPES

Loss of B Cells in Patients with Heterozygous Mutations in IKAROS

2016; Massachusetts Medical Society; Volume: 374; Issue: 11 Linguagem: Inglês

10.1056/nejmoa1512234

1533-4406

Hye Sun Kuehn, Bertrand Boisson, Charlotte Cunningham‐Rundles, Janine Reichenbach, Asbjørg Stray‐Pedersen, Erwin W. Gelfand, Patrick Maffucci, Keith R. Pierce, Jordan K. Abbott, Karl V. Voelkerding, Sarah T. South, Nancy H. Augustine, Jeana S. Bush, William K. Dolen, Betty B. Wray, Yuval Itan, Aurélie Cobat, Hanne Sørmo Sorte, Sundar Ganesan, Seraina Prader, Thomas B. Martins, Monica G. Lawrence, Jordan S. Orange, Katherine R. Calvo, Julie E. Niemela, Jean‐Laurent Casanova, Thomas A. Fleisher, Harry R. Hill, Attila Kumánovics, Mary Ellen Conley, Sergio D. Rosenzweig,

Acute Lymphoblastic Leukemia research

Common variable immunodeficiency (CVID) is characterized by late-onset hypogammaglobulinemia in the absence of predisposing factors. The genetic cause is unknown in the majority of cases, and less than 10% of patients have a family history of the disease. Most patients have normal numbers of B cells but lack plasma cells.