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History of the development of pertussis vaccine.

1991; National Institutes of Health; Volume: 73; Linguagem: Inglês

Margaret Pittman,

Bacterial Infections and Vaccines

Bordetella pertussis and the disease whooping cough have mysterious unique features among bacterial infectious diseases. Numerous studies gradually provided information that permitted the development of a pertussis vaccine and the assessment of its potency relative to human efficacy. The advances in the understanding of B. pertussis, its pathogenicity and immunity that led to the development of a pertussis vaccine are presented.