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Vascular Integrity in the Pathogenesis of Brain Arteriovenous Malformation

2016; Springer Science+Business Media; Linguagem: Inglês

10.1007/978-3-319-18497-5_6

2197-8395

Rui Zhang, Wan Zhu, Hua Su,

Intracranial Aneurysms: Treatment and Complications

Brain arteriovenous malformation (bAVM) is an important cause of intracranial hemorrhage (ICH), particularly in the young population. ICH is the first clinical symptom in about 50 % of bAVM patients. The vessels in bAVM are fragile and prone to rupture, causing bleeding into the brain. About 30 % of unruptured and non-hemorrhagic bAVMs demonstrate microscopic evidence of hemosiderin in the vascular wall. In bAVM mouse models, vascular mural cell coverage is reduced in the AVM lesion, accompanied by vascular leakage and microhemorrhage. In this review, we discuss possible signaling pathways involved in abnormal vascular development in bAVM.