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Artigo Acesso aberto Produção Nacional Revisado por pares
BIBTEX RIS

Cationic Pd(II) complexes acting as topoisomerase II inhibitors: Synthesis, characterization, DNA interaction and cytotoxicity

2016; Elsevier BV; Volume: 159; Linguagem: Inglês

10.1016/j.jinorgbio.2016.02.039

ISSN

1873-3344

Autores

Fillipe V. Rocha, Vincent Barra, Saulo Santesso Garrido, Francine Alessandra Manente, Iracilda Zeppone Carlos, Javier Ellena, Andrea S. C. Fuentes, Arnaud Gautier, Laurent Morel, Antônio E. Mauro, Adelino V.G. Netto,

Tópico(s)

Synthesis and biological activity

Resumo

The synthesis and characterization of the complexes [PdX(PPh 3 )(4-MeT)]X (4-MeT = 4-methyl-3-thiosemicarbazide; PPh 3 = triphenylphosphine; X = Cl, Br, I, SCN) have been described. The complexes were evaluated for in vitro activity as cytotoxic agents on tumor cells and also as cathepsin B and topoisomerase I and II inhibitors. • Cationic palladium compounds were prepared bearing thiosemicarbazide and triphenylphosphine. • The compounds were more cytotoxic than cisplatin against LM3 and MCF-7 tumor cells. • The complexes interact with topoisomerase II more efficiently than etoposide. • Cathepsin B activity is inhibited by Pd(II) compounds.

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