Produção Nacional
Revisado por pares
Influence of Cytokines and Soluble Receptors in the Quality of Life and Functional Capacity of Workers Exposed to Silica
2016; Lippincott Williams & Wilkins; Volume: 58; Issue: 3 Linguagem: Inglês
10.1097/jom.0000000000000606
ISSN1536-5948
AutoresNayara Felicidade Tomaz Braz, Ana Paula Scalia Carneiro, Núbia Carelli Pereira de Avelar, Aline Silva de Miranda, Ana Cristina Rodrigues Lacerda, Mauro Martins Teixeira, Antônio Lúcio Teixeira, Vanessa Amaral Mendonça,
Tópico(s)Biomarkers in Disease Mechanisms
ResumoObjectives: The aim of the study was to evaluate the plasma levels of inflammatory mediators in subjects exposed to silica, with and without silicosis compared with unexposed control group; and to check the association between inflammatory mediators with pulmonary function, quality of life, functional capacity, and dyspnea grade. Methods: Inflammatory mediators were measured by enzyme-linked immunosorbent assay. There were 30 subjects exposed to silica and 24 control group. Results: Interleukin-6 plasma levels were higher in subjects exposed to silica with and without silicosis than in the control group. There was a positive correlation between radiological severity and the quality of life, whereas there was a negative correlation between radiological severity and pulmonary function. A negative correlation between sTNFR1 plasma level and functional capacity was found. Interleukin-10 was negatively correlated with the quality of life total score and was positively correlated with the functional capacity and pulmonary function.
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