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Estudo da variação sazonal dos parâmetros bioquímicos de roedores e lagomorfos do Biotério da Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brasil*

2014; Sociedade de Medicina Veterinária do Estado do Rio de Janeiro; Volume: 36; Issue: 2 Linguagem: Inglês

2527-2179

Marilda Osti Spinelli, Robison José da Cruz, Cyntia Marques dos Santos Correa de Godoy, Milena Coutinho da Motta, Sueli Blanes Damy,

Atherosclerosis and Cardiovascular Diseases

ABSTRACT. Spinelli M.O., da Cruz R.J., de Godoy C.M.S.C., Motta M.C. & Damy S.B. [Study of seasonal variation biochemical parameters of rodents and lagomorphs from the Vivarium of the Faculty of Medicine, University of Sao Paulo, Sao Paulo, Brazil.] Estudo da variacao sazonal dos parâmetros bioquimicos de roedores e lagomorfos do bioterio da Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, Brasil. Revista Brasileira de Medicina Veterinaria, 36(2):219-225, 2014. Faculdade de Medicina, Divisao Tecnica de Apoio ao Ensino e Pesquisa, Bioterio Central, Avenida Doutor Arnaldo, 455, Cerqueira Cesar, Sao Paulo, SP 01246-903, Brasil. E-mail: marilda@biot.fm.usp.br This work aimed to study the seasonal variation of the biochemical parameters of mice inbred BALB / c and C57BL / 6 mice, rats and rabbits New Zealand, the Vivarium of the Faculty of Medicine, University of Sao Paulo. Which is its clinical significance, assessing the analytes plasma ALT (alanine aminotransferase), AST (aspartate aminotransaminase), urea, urea-BUN (blood urea nitrogen), creatinine, total cholesterol and fractions VLDL (very low density lipoprotein), HDL (high density lipoprotein) and LDL (low density lipoprotein)? The results showed an increase in concentrations of analytes, statistical significance, especially in summer. The hypotheses that causes nutritional, infectious, water stress or climatic variations did not affect them, suggesting that to assess the health status of colonies of laboratory animals, biochemical parameters must be considered within the range of variation expected for each colony under study.