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Penicillin-induced hemolytic anemia and acute hepatic failure following treatment of tetanus in a horse.

1991; National Institutes of Health; Volume: 81; Issue: 1 Linguagem: Inglês

D. L. Step, Julia T. Blue, Stephen G. Dill,

Botulinum Toxin and Related Neurological Disorders

Acute, severe hemolytic anemia occurred in a horse being treated for tetanus with intravenous penicillin and tetanus antitoxin. During treatment, the horse developed a positive direct antiglobulin test and a high titer (maximum 1:1024) of IgG anti-penicillin antibody. The horse recovered from the tetanus and penicillin induced hemolytic anemia, but later developed acute hepatic failure, probably resulting from the administration of equine origin tetanus antitoxin.