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Neural basis of reward anticipation and its genetic determinants

2016; National Academy of Sciences; Volume: 113; Issue: 14 Linguagem: Inglês

10.1073/pnas.1503252113

1091-6490

Tianye Jia, Christine Macare, Sylvane Desrivières, Dante A. Gonzalez, Chenyang Tao, Xiaoxi Ji, Barbara Ruggeri, Frauke Nees, Tobias Banaschewski, Gareth J. Barker, Arun L.W. Bokde, Uli Bromberg, Christian Büchel, Patricia Conrod, Rachel Dove, Vincent Frouin, Jürgen Gallinat, Hugh Garavan, Penny Gowland, Andreas Heinz, Bernd Ittermann, Mark Lathrop, Hervé Lemaître, Jean‐Luc Martinot, Tomáš Paus, Zdenka Pausová, Jean‐Baptiste Poline, Marcella Rietschel, Trevor W. Robbins, Michael N. Smolka, Christian P. Müller, Jianfeng Feng, Adrian Rothenfluh, Herta Flor, Günter Schumann, Lisa Albrecht, Mercedes Arroyo, Éric Artiges, Semiha Aydın, Christine Bach, Tobias Banaschewski, Alexis Barbot, Gareth J. Barker, Arun L.W. Bokde, Zuleima Bricaud, Uli Bromberg, Ruediger Bruehl, Christian Büchel, Anna Cattrell, Patricia Conrod, Katharina Czech, Jeffrey W. Dalley, Sylvane Desrivières, Tahmine Fadai, Herta Flor, Vincent Frouin, Jürgen Gallinat, Hugh Garavan, Fanny Gollier Briand, Penny Gowland, Bert Heinrichs, Andreas Heinz, Thomas Hübner, Albrecht Ihlenfeld, Alex Ing, Bernd Ittermann, Tianye Jia, Jennifer Jones, Eleanor Kennedy, Dirk Lanzerath, Mark Lathrop, Claire Lawrence, Hervé Lemaître, Katharina Lüdemann, Christine Macare, Karl Mann, Adam C. Mar, Jean‐Luc Martinot, Eva Mennigen, Fabiana Mesquita de Carvahlo, Kathrin Müller, Frauke Nees, Charlotte Nymberg, Marie-Laure Paillère, Tomáš Paus, Zdenka Pausová, Jean‐Baptiste Poline, Luise Poustka, Erin Burke Quinlan, J.H. Reuter, Stephan Ripke, Trevor W. Robbins, Guillaume Robert, Sarah Rodehacke, Barbara Ruggeri, Barbara Ruggeri, Dirk Schmidt, Sophia Schneider, Herta Flor, Michael N. Smolka, Wolfgang H. Sommer, Rainer Spanagel, Claudia Speiser, Tade Matthias Spranger, Alicia Stedman, D.N. Stephens, Nicole Strache, Andreas Ströhle, Maren Struve, Naresh Subramaniam, Amir Tahmasebi, David Theobald, Nora C. Vetter, Hélène Vulser, Bernadeta Walaszek, Robert Whelan, Steven Williams, Bing Xu, Juliana Yacubian, Veronika Ziesch,

Cognitive Abilities and Testing

Significance We characterize in humans a coordinated network of brain activity describing neurobehavioral correlates of reward anticipation. The network involves nodes in striatal and cortical brain regions, which are preferentially associated with distinct externalizing behaviors—hyperactivity and alcohol consumption—suggesting that the heterogeneity of reward-related behaviors might be accounted for by different association patterns of nodes and their connecting links. In a genome-wide association study of the striatal node with subsequent functional validation in Drosophila , we identify molecular genetic mechanisms involving vacuolar protein sorting-associated protein 4A ( VPS4A ) in dopamine regulation, reward anticipation, and hyperactivity. Our approach might facilitate the identification of causal neural mechanisms, important for the identification of previously unidentified targets and the establishment of neurobehaviorally informed end points for clinical trials.