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Artigo Acesso aberto Produção Nacional Revisado por pares
BIBTEX RIS

Evaluation of ent -Kaurenoic Acid Derivatives for their Anticariogenic Activity

2011; SAGE Publishing; Volume: 6; Issue: 6 Linguagem: Inglês

10.1177/1934578x1100600608

ISSN

1934-578X

Autores

Bruna B. de Andrade, Monique Rodrigues Moreira, Sérgio Ricardo Ambrósio, Niege Araçari Jacometti Cardoso Furtado, Wilson Roberto Cunha, Vladimir Constantino Gomes Heleno, Aline N. Silva, Marília R. Simão, Erilda M. P. da Rocha, Carlos Henrique Gomes Martins, Rodrigo Cássio Sola Veneziani,

Tópico(s)

Essential Oils and Antimicrobial Activity

Resumo

Ent-kaur-16(17)-en-19-oic acid (kaurenoic acid, KA) is a tetracyclic diterpene prototype for natural anticaries agents. Six KA derivatives were prepared and their antimicrobial activity against the main microorganisms involved in the caries process evaluated. The sodium salt of KA (KA-Na) was the most active, displaying very promising MIC values for most pathogens. Time-kill assays against the primary causative agent of caries (Streptococcus mutans) indicated that KA and KA-Na only inhibited growth in the first 12 h, suggesting a bacteriostatic effect. After this period (12-24 h), their bactericidal effect was clearly noted. KA and KA-Na showed no synergy when combined with the gold standard anticariogenic (chlorhexidine dihydrochloride, CHD) in the checkerboard assays against S. mutans.

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