Chemicopharmacological Studies on Antispasmodic Action. VII. Antagonism to Acetylcholine tested with Rectus Abdominis of Frog.
1957; Pharmaceutical Society of Japan; Volume: 5; Issue: 3 Linguagem: Inglês
10.1248/cpb1953.5.247
ISSN1881-1345
AutoresKeijiro Takagi, Issei Takayanagi,
Tópico(s)Analytical Methods in Pharmaceuticals
ResumoIt was concluded statistically on the contraction of rectus abdominis of a frog that : 1) The reaction between ACh and its receptor in the muscle obeyed Clark's formula and the reaction order was 1, that is, they react with one molecule each. 2) Reaction mechanism between ACh and its receptor was different in the presence of eserine, from that in its absence. 3) Antagonism of atropine and d-tubocurarine to ACh obeyed Gaddum's formula as competitive. 4) One molecule of d-tubocurarine antagonized two mo■ecules of ACh ; two ammonium nitrogens in d-tubocurarine antagonized one molecule of ACh each.
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