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Gas Chromatographic Fid, Hypoglycemic and Hypolipidemic Effects Of Leaves Of Laportea Aestuans In Alloxan Induced Diabetes In Male Albino Rats

2014; International organization of Scientific Research (IOSR); Volume: 8; Issue: 1 Linguagem: Inglês

10.9790/2402-08124246

2319-2402

Stanley Chukwuma Okereke, I Elekwa, N Asamudo U,

Liver Disease Diagnosis and Treatment

Gas chromatophic FID analysis of leaves of Laportea aestuans was conducted and showed the presence of polyphenols, flavonoids, terpenes, carotenoids and saponins.The effects of Laportea (Linn) on alloxan induced diabetes in rats were also evaluated using glucose and lipid profiles.Animals weighing (160 -200g) were divided into 3 groups of 21 animals each; Group 1 (normal control), Group 2 (diabetes control) and Group 3 (test).Diabetes was induced in albino rats by intraperitoneal injection of alloxan in group 2 and 3 respectively.Animals in group 1 and 2 received normal rat feed while animals in group 3 were fed with Laportea aestuans leaves for a period of 28 days.Animals were sacrificed on day 28.Glucose, glycated hemoglobin and lipid profile were estimated.Laportea aestuans leaves elicited significant (P<0.05)reduction of blood glucose and lipid profile parameters except high density lipoprotein cholesterol (HDL-C) which significantly increased.L. aestuans offer promise as antidiabetic and antihyperlipidemia.