Produção Nacional
The Contribution of Natural Products as Source of New Anticancer Drugs: Studies Carried Out at the National Experimental Oncology Laboratory from the Federal University of Ceará
2010; Brazilian Society of Chemistry; Volume: 2; Issue: 1 Linguagem: Inglês
10.5935/1984-6835.20100006
ISSN1984-6835
AutoresLetícia V. Costa‐Lotufo, Raquel Carvalho Montenegro, Ana Paula Negreiros Nunes Alves, Socorro Vanesca Frota Madeira, Cláudia Pessoa, Maria Elisabete Amaral de Moraes, Manoel O. de Moraes,
Tópico(s)Plant tissue culture and regeneration
ResumoThe history of anticancer chemotherapy is closely related to that of natural products, as over 60% of currently used drugs in cancer therapy are natural products or inspired by a natural compound.Despite the introduction of new drugs in the therapeutic arsenal of anticancer medicines, many tumors do not properly respond to treatment.Natural resources comprise the most promising possibilities of finding new and efficient molecules with impact in the therapy of resistant diseases.The National Experimental Oncology Laboratory began a research program aiming at the evaluation of new natural or synthetic anticancer molecules through an experimental approach involving in vitro and in vivo models.In the period between 2000 and 2007, 5166 samples were screened, and three molecules, piplartine, biflorine and pisosterol, were selected for further studies.
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