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Sirtuins, Aging, and Medicine

2011; Massachusetts Medical Society; Volume: 364; Issue: 23 Linguagem: Inglês

10.1056/nejmra1100831

1533-4406

Leonard Guarente,

Autophagy in Disease and Therapy

In this year's Franklin H. Epstein Lecture, Leonard Guarente summarizes the many biologic properties of the sirtuin family of deacetylases and explains why enhancement or inhibition of specific sirtuins may influence many common diseases and longevity.