Artigo Revisado por pares

Regeneration of bone from periosteum

1912; SAGE Publishing; Volume: 10; Issue: 2 Linguagem: Inglês

10.3181/00379727-10-41

ISSN

1535-3702

Autores

S. L. Haas,

Tópico(s)

Congenital limb and hand anomalies

Resumo

In an endeavor to establish the factor that periosteum plays in the regeneration of bone, the following experiments were performed on the ribs of rabbits. Several experiments consisting merely of a subperiosteal resection of the rib showed after 20 days a cartilaginous-like material filling the entire space; while after a longer time complete filling in with bone. The next endeavor was to isolate the periosteum so as to prevent bony elements from growing in to the periosteal space. In one experiment the rib ends were capped with lead—after 12 days no evidence of regeneration. This method was discarded as it was thought better to try and raise the rib from its periosteal covering without severing the ends, and isolate it by sewing muscle beneath the raised rib. In 10 experiments of this nature the results uniformly showed a tendency for bone to grow in at the angle where the rib was raised from its periosteal bed. In one experiment after 59 days the whole area was filled in by bone, although in another after 8 months there was only a small spicule of bone growing in at the sternal side. In only one experiment after 26 days was an isolated island of bone found, free from connection with bone elements. Although this does not prove the point sought, it at least emphasizes the tendency of bone to grow in the direction of existing periosteum. At this stage it was noticed that there was a difference at times in bone regeneration and it was suggested to try the effect of blood clot. The experiment was performed in the same way as the previous one except that blood clot was placed in the periosteal gutter left by the raised rib.

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