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BIBTEX RIS

Constitutive expression of genes encoding notch receptors and ligands in developing lymphocytes, nTreg cells and dendritic cells in the human thymus

2016; Elsevier BV; Volume: 6; Linguagem: Inglês

10.1016/j.rinim.2016.04.001

ISSN

2211-2839

Autores

Luciana Bento‐de‐Souza, Jefferson Russo Victor, Luiz C. Bento-de-Souza, Magaly Arrais dos Santos, Andreia Rangel‐Santos, Érica Pereira-Costa, Elaine Raniero-Fernandes, Maria I. Seixas-Duarte, João B. Oliveira-Filho, A.J.S. Duarte,

Tópico(s)

Chemokine receptors and signaling

Resumo

The thymus is the site of T cell maturation. Notch receptors (Notch1-4) and ligands (DLL1-3 and Jagged1-2) constitute one of several pathways involved in this process. Our data revealed differential constitutive expression of Notch genes and ligands in T lymphocytes and thymic dendritic cells (tDCs), suggesting their participation in human thymocyte maturation. nTreg analyses indicated that the Notch components function in parallel to promote maturation in the thymus.

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