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The epimer of kaurenoic acid from Croton antisyphiliticus is cytotoxic toward B-16 and HeLa tumor cells through apoptosis induction

2013; Research Foundation of Ribeirão Preto; Volume: 12; Issue: 2 Linguagem: Inglês

10.4238/2013.april.2.16

1676-5680

Vanessa C. Fernandes, Sarazete Izidia Vaz Pereira, Juliana da Silva Coppede, Juliana Simões Martins, Walace Fraga Rizo, Renê Oliveira Beleboni, Mozart Marins, Paulo Sérgio Pereira, A.M.S. Pereira, Ana Lúcia Fachin,

Phytochemistry and Biological Activities

Cancer has become the leading cause of death in developing countries due to increased life expectancy of the population and changes in lifestyle.Studies on active principles of plant have motivated researchers to develop new antitumor agents that are specific and effective for treatment of neoplasms.Kaurane diterpenes are considered important compounds in the development of new and highly effective anticancer chemotherapeutic agents due to their cytotoxic properties in the induction of apoptosis.We evaluated the cytotoxic and apoptotic activity of the epimer of kaurenoic acid (EKA) isolated from the medicinal plant Croton antisyphiliticus (Euphorbiaceae) toward tumor cell lines HeLa and B-16 and normal fibroblasts 3T3.Based on analyses with the MTT test, EKA showed cytotoxic activity, with half maximal inhibitory concentration values of 59.41, 68.18 and 60.30 µg/ mL for the B-16, HeLa and 3T3 cell lines, respectively.The assay for necrotic or apoptotic cells by differential staining showed induction of apoptosis in all three cell lines.We conclude that EKA is not selective ©FUNPEC-RP www.funpecrp.com.