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Adrenocortical Carcinoma: Prognostic Indices Based on Clinical and Immunohistochemical Markers

2005; De Gruyter; Volume: 18; Issue: 4 Linguagem: Inglês

10.1515/jpem.2005.18.4.347

2191-0251

Vaê Dichtchekenian, Carlos Alberto de Bragança Pereira, Hílton Kuperman, Thaís Della Manna, Durval Damiani, Venâncio Avancini Ferreira Alves, Adhemar Longato Filho, Nuvarte Setian,

Glioma Diagnosis and Treatment

Adrenocortical carcinoma is a rare condition with an unpredictable prognosis as a rule. The authors retrospectively analyzed the clinical outcome of 46 patients (31 F, 15 M) during 16 years building up a numerical index for the prognosis, based on clinical and immunohistochemical data. Four indices were analyzed: J1= (Y + 2L + 4H)/T; J2 = (J1) square root of W/200; J3 = (O + Y + 2L + 4H)/T; J4 = (J3) square root W/200. Y = 1 when chronological age (CA) >33 mo, Y = 0 when CA < or =33 mo; L = 1 for right sided tumor and L = 0 for left sided tumor; H = 1 in presence of hypertension and H = 0 for normal blood pressure; T = length of disease in months; W = weight of tumor (g); O = 1 in the absence of p53 protein and O = 0 in the presence of p53. The chance of bad prognosis was observed when age is >33 mo, tumor is on the right side, systemic hypertension is present, tumor weight >250 g, in the absence of p53, J1, J2, J3 >0.4 (p 0.5 (p <0.01). Clinical data and the mathematical model enabled us to establish probabilities of good prognosis in 78-96% and bad prognosis in 63-83%.