Synthesis of Chiral N -Heterocyclic Carbene Ligands with Rigid Backbones and Application to the Palladium-Catalyzed Enantioselective Intramolecular α-Arylation of Amides
2011; American Chemical Society; Volume: 13; Issue: 7 Linguagem: Inglês
10.1021/ol200149s
ISSN1523-7060
AutoresLantao Liu, Naoki Ishida, Shinji Ashida, Masahiro Murakami,
Tópico(s)Synthetic Organic Chemistry Methods
ResumoChiral N-heterocyclic carbene (NHC) ligands having a 2,2'-bisquinoline-based C(2) symmetric skeleton were developed. The ligands exhibited good enantioselectivity in palladium-catalyzed intramolecular α-arylation of amides to give 3,3-disubsituted oxindoles.
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