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Studies on aldose reductase inhibitors from natural products. II. Active components of a Paraguayan crude drug "para-parai mi," Phyllanthus niruri.

1989; Pharmaceutical Society of Japan; Volume: 37; Issue: 9 Linguagem: Inglês

10.1248/cpb.37.2531

1347-5223

Mineo Shimizu, Syunji HORIE, Satoshi Terashima, Hajime Ueno, Toshimitsu Hayashi, Munehisa Arisawa, Shoichi Suzuki, Masao Yoshizaki, Naokata Morita,

Aldose Reductase and Taurine

Aldose reductase (AR) inhibitory activity-directed fractionation of the 70% ethanolic extract of Para-parai mí, Phyllanthus niruri, has led to the isolation of three active components, ellagic acid (1), brevifolin carboxylic acid (4) and ethyl brevifolin carboxylate (5). Among them, 1 showed the highest inhibitory activity, being about 6 times more potent than quercitrin, which is a known natural inhibitor of AR.