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Immunological Studies in Relation to Suprarenal Gland. VII. Effect of Bilateral Suprarenalectomy on Acquired Resistance in Rats.

1931; SAGE Publishing; Volume: 28; Issue: 6 Linguagem: Inglês

10.3181/00379727-28-5466

1535-3702

J. Marmorston-Gottesman, David Perla,

Adrenal Hormones and Disorders

In previous studies we gathered evidence of the importance of the suprarenal gland in antibody formation through its influence on the water balance in the tissues of the body., , , , That the suprarenal glands are essential in the mechanism of natural resistance has been established by Marine and his coworkers in this laboratory, , , , , and by other investigators., , , , , In an effort to determine the relation of the suprarenal gland to acquired resistance the following experiment was carried out. In a preliminary experiment the M.L.D. of a batch of typhoid vaccine (preparation No. 120, lot No. 199) in suprarenalectomized rats was determined. This was found to be 0.5 cc. Fourteen rats received 3 intraperitoneal injections of typhoid vaccine at weekly intervals (0.5 cc. and 1 cc.). Five days after the last injection these 14 rats were suprarenalectomized, together with 10 normal uninjected rats. On the sixth day following the operation 8 immunized suprarenalectomized rats were injected with 5 cc. of typhoid vaccine and 6 were injected with 1 cc. intraperitoneally. All the unimmunized rats were injected with twice the M.L.D. (1 cc.).