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BIBTEX RIS

New Organochalcogen Multitarget Drug: Synthesis and Antioxidant and Antitumoral Activities of Chalcogenozidovudine Derivatives

2015; American Chemical Society; Volume: 58; Issue: 8 Linguagem: Inglês

10.1021/jm5015296

1520-4804

Diego de Souza, Douglas Oscar Ceolin Mariano, Fernanda Nedel, Eduarda Schultze, Vinícius Farias Campos, Fabiana K. Seixas, Rafael S. da Silva, Taiana S. München, Vinícius Ilha, Luciano Dornelles, Antônio L. Braga, João Batista Teixeira da Rocha, Tiago Collares, Oscar E. D. Rodrigues,

Synthesis and biological activity

In this article we present the synthesis, characterization, and in vitro biological and biochemical activities of new chalcogenozidovudine derivatives as antioxidant (inhibition of TBARS in brain membranes and thiol peroxidase-like activity) as well as antitumoral agents in bladder carcinoma 5637. A prominent response was obtained for the selected chalcogenonucleosides, showing effective antioxidant and antitumoral activities.