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Facile Desulfurization of Thiocarbonyl Groups to Carbonyls by Superoxide. A Model of Metabolic Reactions

1981; Pharmaceutical Society of Japan; Volume: 29; Issue: 10 Linguagem: Inglês

10.1248/cpb.29.3075

1347-5223

Etsu Katori, Tetsuo Nagano, Takehisa Kunieda, Masaaki Hirobe,

Biochemical and Molecular Research

Several types of thioamides and thioureas including thiouracils were readily desulfurized to the carbonyl compounds by superoxide, generated by KO2 and 18-crown-6 or electrolysis of oxygen in aprotic solvent at room temperature. Such desulfurization may provide a model of metabolic reactions catalyzed by oxygenases.