Fluvirucins A1, A2, B1, B2, B3, B4 and B5, new antibiotics active against influenza a virus. I. Production, isolation, chemical properties and biological activities.
1991; Springer Nature; Volume: 44; Issue: 7 Linguagem: Inglês
10.7164/antibiotics.44.733
ISSN1881-1469
AutoresNOBUAKI NARUSE, Osamu Tenmyo, Kimio Kawano, Koji Tomita, NORIYUKI OHGUSA, Takeo Miyaki, MASATAKA KONISHI, TOSHIKAZU OKI,
Tópico(s)Glycosylation and Glycoproteins Research
ResumoFive unidentified actinomycete strains produced a series of novel antiviral antibiotics which have a unique 2, 6-dialkyl-10-ethyl-3(or 9)-hydroxy-13-tridecanelactam nucleus substituted with 3-amino-3, 6-dideoxy-L-talose or 3-amino-3, 6-dideoxy-L-mannose(L-mycosamine). The antibiotic components exhibited potent inhibitory activity against influenza virus type A Victoria strain infection in Madin Darby canine kidney cells by the cytopathic effect reduction assay.
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