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Maripa Hantavirus in French Guiana: Phylogenetic Position and Predicted Spatial Distribution of Rodent Hosts

2014; American Society of Tropical Medicine and Hygiene; Volume: 90; Issue: 6 Linguagem: Inglês

10.4269/ajtmh.13-0257

1476-1645

Benoı̂t de Thoisy, Séverine Matheus, François Catzeflis, Luc Clément, Sébastien Barrioz, Amandine Guidez, Damien Donato, Jean‐François Cornu, Olivier Brunaux, Stéphane Guitet, Vincent Lacoste, Anne Lavergne,

Viral Infections and Outbreaks Research

A molecular screening of wild-caught rodents was conducted in French Guiana, South America to identify hosts of the hantavirus Maripa described in 2008 in a hantavirus pulmonary syndrome (HPS) case. Over a 9-year period, 418 echimyids and murids were captured. Viral RNA was detected in two sigmodontine rodents, Oligoryzomys fulvescens and Zygodontomys brevicauda , trapped close to the house of a second HPS case that occurred in 2009 and an O. fulvescens close to the fourth HPS case identified in 2013. Sequences from the rodents had 96% and 97% nucleotide identity (fragment of S and M segments, respectively) with the sequence of the first human HPS case. Phylogenetic reconstructions based on the complete sequence of the S segment show that Maripa virus is closely related to Rio Mamore hantavirus. Using environmental descriptors of trapping sites, including vegetation, landscape units, rain, and human disturbance, a maximal entropy-based species distribution model allowed for identification of areas of higher predicted occurrence of the two rodents, where emergence risks of Maripa virus are expected to be higher.