Portal de Periódicos da CAPES

Case Study of Small Molecules As Antimalarials: 2-Amino-1-phenylethanol (APE) Derivatives

2014; American Chemical Society; Volume: 5; Issue: 6 Linguagem: Inglês

10.1021/ml500015r

1948-5875

María J. Chaparro, Jaume Vidal, Íñigo Angulo‐Barturen, José M. Bueno, Jeremy N. Burrows, N. Cammack, Pablo Castañeda, Gonzalo Colmenarejo, José M. Coterón, Laura de las Heras, Esther Fernández, Santiago Ferrer, Raquel Gabarró, Francisco‐Javier Gamo, Mercedes García, Marı́a Belén Jiménez-Dı́az, María José Lafuente, María Luisa León, María Santos Martínez, Douglas J. Minick, Sara Prats, Margarita Puente, Lourdes Rueda, Elena Sandoval, Ángel Santos-Villarejo, Michael J. Witty, Félix Calderón,

Computational Drug Discovery Methods

Antiparasitic oral drugs have been associated to lipophilic molecules due to their intrinsic permeability. However, these kind of molecules are associated to numerous adverse effects, which have been extensively studied. Within the Tres Cantos Antimalarial Set (TCAMS) we have identified two small, soluble and simple hits that even presenting antiplasmodial activities in the range of 0.4–0.5 μM are able to show in vivo activity.