Portal de Periódicos da CAPES

Faecal gas analysis by electronic nose as novel, non-invasive method for assessment of active and quiescent paediatric inflammatory bowel disease: Proof of principle study

2014; Oxford University Press; Linguagem: Inglês

10.1016/j.crohns.2014.09.004

1876-4479

Tim G. J. de Meij, Nanne K.H. de Boer, Marc A. Benninga, Yvette E. Lentferink, E. F. J. de Groot, Mirjam E. van de Velde, Adriaan A. van Bodegraven, Marc P. van der Schee,

Olfactory and Sensory Function Studies

Inflammatory bowel disease (IBD) and its two phenotypes ulcerative colitis (UC) and Crohn's disease (CD) are essentially assessed by endoscopy, both in initial diagnostic work-up and during follow-up. This carries a high burden, especially on paediatric patients. Faecal volatile organic compounds (VOCs) are considered potential non-invasive biomarkers for intestinal diseases linked to gut microbiota alterations. We hypothesized that faecal VOC analysis by electronic nose allows discrimination of children with CD, UC and controls during active disease and remission.