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Bioavailability of sugar-coated tablets of thiamine disulfide in humans. II. Correlation with bioavailability in beagle dogs.

1986; Pharmaceutical Society of Japan; Volume: 34; Issue: 1 Linguagem: Inglês

10.1248/cpb.34.292

1347-5223

Nobuo Aoyagi, Hiroyasu Ogata, Nahoko Kaniwa, Masanobu Koibuchi, TOSHIO SHIBAZAKI, Akira Ejima, Masakazu Mizobe, KEIICHI KOHNO, Masayoshi Samejima,

Metabolism and Genetic Disorders

The bioavailabilities of six brands of thiamine disulfide (TDS) sugar-coated tablets were investigated in male beagle dogs and the correlations with the bioavailabilities in humans and the in vitro dissolution rates were investigated. the volume of water coadministered with the drug did not affect the bioavailability. The bioavailabilities of slow-dissolving products at pH 3-7.2 under the weakly destructive conditions of the paddle and rotating basket methods were relatively higher in dogs than in humans, which suggested a stronger disintegration force in dogs. Gastric fluid pH seemed to affect the in vivo dissolution of TDS itself. The in vivo parameters in dogs correlated significantly with the dissolution rate, disintegration time and in vivo parameters in high gastric acidity humans, with the exception of one product.