Portal de Periódicos da CAPES

An approach to (±)-Lingzhiol

2016; American Chemical Society; Volume: 18; Issue: 8 Linguagem: Inglês

10.1021/acs.orglett.6b00542

1523-7060

Xiaoyu Li, Xiaoyu Liu, Xiaozhen Jiao, Hongguang Yang, Yangyang Yao, Ping Xie,

Fungal Biology and Applications

(±)-Lingzhiol has been synthesized from commercially available 5,8-dimethoxytetralone in seven steps with an overall yield of 10.3% via an unprecedented acid-catalyzed semipinacol-type rearrangement. In addition, a novel strategy for the construction of the tetracyclic 5/5/6/6 core structure of lingzhiol has been developed via a tandem rearrangement/reduction/lactonization reaction.