Palladium-Catalyzed Ortho-Alkoxylation of Anilides via C–H Activation
2012; American Chemical Society; Volume: 77; Issue: 21 Linguagem: Inglês
10.1021/jo301964m
ISSN1520-6904
Autores Tópico(s)Catalytic Cross-Coupling Reactions
ResumoA palladium-catalyzed ortho-alkoxylation of anilides with both primary and secondary alcohols via ligand-directed C-H activation has been explored. This alkoxylation promoted by catalytic methanesulfonic acid proceeds well at room temperature in most cases and affords aryl alkyl ethers in moderate to good yields.
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