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Reconstructed Stem Cell Nanoghosts: A Natural Tumor Targeting Platform

2013; American Chemical Society; Volume: 13; Issue: 7 Linguagem: Inglês

10.1021/nl401376w

1530-6992

Naama E. Toledano Furman, Yael Lupu‐Haber, Tomer Bronshtein, Limor Kaneti, Nitzan Letko, Eyal Weinstein, Limor Baruch, Marcelle Machluf,

Nanoplatforms for cancer theranostics

The ultimate goal in cancer therapy is achieving selective targeting of cancer cells. We report a novel delivery platform, based on nanoghosts (NGs) produced from the membranes of mesenchymal stem cells (MSCs). Encompassing MSC surface molecules, the MSC-NGs retained MSC-specific in vitro and in vivo tumor targeting capabilities and were cleared from blood-filtering organs. MSC-NGs were found to be biocompatible. Systemic administration of drug loaded MSC-NGs demonstrated 80% inhibition of human prostate cancer.