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Toxicity of Nano Molybdenum Trioxide toward Invasive Breast Cancer Cells

2014; American Chemical Society; Volume: 6; Issue: 4 Linguagem: Inglês

10.1021/am405586d

1944-8252

Thao Anh Tran, Karthikeyan Krishnamoorthy, Yeon Woo Song, Somi Kim Cho, Sang‐Jae Kim,

Nanoparticle-Based Drug Delivery

Current chemotherapy is limited by the nature of invasive cancer cells, which are similar to cancer stem cells. Nanomaterials provide a potential alternate mode of cancer therapy. This study investigated the cytotoxicity of molybdenum trioxide (MoO3) nanoplates toward invasive breast cancer iMCF-7 cells by analyzing morphological changes and performing Western blot and flow cytometry analyses. The findings suggested that MoO3 exposure induces apoptosis and generates reactive oxygen species (ROS) in iMCF-7 cells. This study revealed the potential utility of MoO3 for treating metastatic cancer cells, which might enable advancements in cancer therapy.