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Sesquiterpene lactones from Cichorium endivia L. and C. intybus L. and cytotoxic activity.

1988; Pharmaceutical Society of Japan; Volume: 36; Issue: 7 Linguagem: Inglês

10.1248/cpb.36.2423

1347-5223

Mamoru Seto, Toshio Miyase, Kaoru Umehara, Akira Ueno, Yutaka Hirano, Norio Otani,

Botanical Research and Chemistry

Four new sesquiterpene lactones, cichoriolide A and cichoriosides A, B and C, have been isolated from Cichorium endivia L. and C. intybus L., together with nine known sesquiterpene lactones. The structures of the new compounds were established on the basis of chemical and spectral data. Further, the cytotoxic activities of related glycosides and the aglycones were compared in the L-5178Y cultured cell system.