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Term-seq reveals abundant ribo-regulation of antibiotics resistance in bacteria

2016; American Association for the Advancement of Science; Volume: 352; Issue: 6282 Linguagem: Inglês

10.1126/science.aad9822

1095-9203

Daniel Dar, Maya Shamir, J. R. Mellin, Mikael Koutero, Noam Stern‐Ginossar, Pascale Cossart, Rotem Sorek,

Bacterial Genetics and Biotechnology

How bacteria switch between tracks Bacterial riboswitches prevent the formation of full-length messenger RNA, and hence proteins, via transcriptional termination in response to metabolites. However, identifying riboswitches within the genome has previously required comparative analysis, which may miss species- and environmentally specific responses. Dar et al. developed a method called term-seq to document all riboswitches in a bacterial genome, as well as their metabolite counterparts (see the Perspective by Sommer and Suess). The method revealed a role for pathogenic bacterial riboswitches in antibiotic resistance. Thus, transcription may be one way pathogens fend off antibiotic attack. Science , this issue p. 10.1126/science.aad9822 ; see also p. 144