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Pathophysiology of anaphylaxis

2011; Lippincott Williams & Wilkins; Volume: 11; Issue: 4 Linguagem: Inglês

10.1097/aci.0b013e3283481ab6

1528-4050

Bilal Khan, Stephen F. Kemp,

Mast cells and histamine

Purpose of review This review aims to provide an overview of the evolving understanding of the pathophysiology of anaphylaxis. Recent findings Immunopathologic mechanisms of anaphylaxis have traditionally focused on the IgE-dependent and IgE-independent release of mediators from mast cells and basophils. There are accumulating data supporting the significance of alternative pathways of anaphylaxis. Increasing attention has also focused on the internal compensatory mechanisms activated in response to anaphylaxis. Summary Recent advances will enhance understanding of the pathophysiology of anaphylaxis and might have future implications for diagnosis and management.