Portal de Periódicos da CAPES

Immunochemotherapy of Visceral Leishmaniasis: A Pilot Trial of Sequential Treatment with Recombinant Interferon-γ and Pentavalent Antimony

1993; Mary Ann Liebert, Inc.; Volume: 13; Issue: 1 Linguagem: Inglês

10.1089/jir.1993.13.39

2332-4007

Gundel Harms, K. Zwingenberger, Beate Sandkamp, Simone Omena, Célia Maria Silva Pedrosa, Joachim Richter, F. Rosenkaimer, Hermann Feldmeier, U Bienzle,

Eosinophilic Disorders and Syndromes

The clinical, parasitological, hematological, and serological evolution of visceral leishmaniasis in Brazilian patients was assessed during treatment with human recombinant interferon-gamma (rIFN-gamma; 0.1 mg/m2 i.m. days 1-14) followed by pentavalent antimony (Sbv; 10 mg/kg days 22-28). At day 30, 6 patients had improved, 2 had slightly improved, and 1 patient had deteriorated. IFN-gamma was well tolerated in the dose tested and may be very effective as an adjunct to conventional therapy with antimony.