Portal de Periódicos da CAPES

Prevalence of urinary tract infection among HIV patients in Aba, Nigeria

2016; Elsevier BV; Volume: 45; Linguagem: Inglês

10.1016/j.ijid.2016.02.517

1878-3511

Adaobi Kanu, N. Mgbajiaka, N. Abadom,

Reproductive tract infections research

Background: People living with Human Immunodeficiency Virus (HIV) are more prone to opportunistic infection including urinary tract infection (UTI) due to progressive immune dysfunction by the virus. The study was conducted to determine the prevalence of UTI among HIV patients attending Seventh Day Adventist Hospital Aba (SDA) for routine antiretroviral therapy as well as the effect of CD4+ count on the prevalence of UTI. Methods & Materials: Clean catch mid stream urine and blood was collected from 104 HIV positive patients between June 2015 – September 2015 comprising of 35 men and 69 women. The HIV patients consisted of 67 highly active antiretroviral therapy (HAART) subjects and 37 HAART naïve subjects. Urine samples were cultured, isolates identified and antibiogram was carried out using standard microbiological procedures. CD4+ T-cell counts were measured by the FACS count system using the FACS flow cytometer. Results: The overall prevalence of UTI was 40.39% with 52.17% occurring in females and 17.14% in males which was statistically significant. Escherichia coli (68.18%) was the most predominant isolated pathogen followed by Klebsiella pneumonia (15.91%), Enterobacter spp (11.36%) and Staphylococcus aureus (4.55%). In the relationship between UTI and CD4+ count a greater percentage of UTI infected participants had CD4+ count greater than 200 cell/μl (41.33%) than those with CD4+ < 200 cell/μl (37.93%) which was statiscally non significant. Age group 60 – above had the highest prevalence of 100% followed by age group 30 – 44 (44.9%) which was statistically non significant cell/μl . Only HIV patients on HAART had non significantly higher prevalence of UTI compared with non HAART users (41.79% vs 37.84%) (P > 0.05). The antibiogram showed that the drugs of choice were gentamycin (93.18%) and ciprofloxacin (72.73%). Most bacterial isolates were resistant to nalidixic acid (84.09%), trimethoprim – sulfamethoxazole (63.63%) and Ampicillin (56.09%). Conclusion: This study draws attention to high prevalence of UTI among HIV patients in Aba metropolitan. Therefore, there is need for HIV patients to be examined for UTI.