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DNA Polymerase β Inhibitors from Sandoricum k oetjape

1999; American Chemical Society; Volume: 62; Issue: 8 Linguagem: Inglês

10.1021/np990104r

1520-6025

Di-An Sun, Shelley Starck, Edward P. Locke, Sidney M. Hecht,

Phytochemical compounds biological activities

Bioassay-guided fractionation of Sandoricum koetjape using an assay sensitive to DNA polymerase β inhibition led to the isolation of three active compounds (1−3) having IC50 values from 20 to 36 μM. Derivatives 5−14 were prepared from compounds 1 and 2; derivatives 11, 12, and 13 showed activity against DNA polymerase β with IC50 values ranging from 16 to 36 μM.