Septins in the glial cells of the nervous system
2013; De Gruyter; Volume: 395; Issue: 2 Linguagem: Inglês
10.1515/hsz-2013-0240
ISSN1437-4315
AutoresJulia Patzig, Michelle S. Dworschak, Ann‐Kristin Martens, Hauke Werner,
Tópico(s)Nerve injury and regeneration
ResumoAbstract The capacity of cytoskeletal septins to mediate diverse cellular processes is related to their ability to assemble as distinct heterooligomers and higher order structures. However, in many cell types the functional relevance of septins is not well understood. This minireview provides a brief overview of our current knowledge about septins in the non-neuronal cells of the vertebrate nervous system, collectively termed ‘glial cells’, i.e., astrocytes, microglia, oligodendrocytes, and Schwann cells. The dysregulation of septins observed in various models of myelin pathology is discussed with respect to implications for hereditary neuralgic amyotrophy (HNA) caused by mutations of the human SEPT9 -gene.
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