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Benzanthrins A and B, a new class of quinone antibiotics. I Discovery, fermentation and antibacterial activity.

1986; Springer Nature; Volume: 39; Issue: 11 Linguagem: Inglês

10.7164/antibiotics.39.1509

1881-1469

Robert J. Theriault, Ronald R. Rasmussen, William L. Kohl, Joseph F. Prokop, Thomas B. Hutch, GRANT J. BARLOW,

Plant Pathogens and Fungal Diseases

Nocardia lurida has been shown to produce two novel quinone antibiotics, benzanthrins A and B. The antibiotics were discovered in concentrated butanol extracts of fermentation broths and were separated by TLC and HPLC. Benzanthrins A and B were produced in a fermentation medium consisting of glucose, yeast, selected peptones and CaCO3. The antibiotics were present primarily at 66 hours in shake flask fermentations and from 66 to 162 hours in 14-liter fermentors. Benzanthrins A and B inhibited a number of Gram-positive pathogenic bacteria but were inactive against Gram-negative bacteria.