Portal de Periódicos da CAPES

miRWalk Database for miRNA–Target Interactions

2014; Springer Science+Business Media; Linguagem: Inglês

10.1007/978-1-4939-1062-5_25

1940-6029

Harsh Dweep, Norbert Gretz, Carsten Sticht,

RNA modifications and cancer

miRWalk (http://mirwalk.uni-hd.de/) is a publicly available comprehensive resource, hosting the predicted as well as the experimentally validated microRNA (miRNA)–target interaction pairs. This database allows obtaining the possible miRNA-binding site predictions within the complete sequence of all known genes of three genomes (human, mouse, and rat). Moreover, it also integrates many novel features such as a comparative platform of miRNA-binding sites resulting from ten different prediction datasets, a holistic view of genetic networks of miRNA–gene pathway, and miRNA–gene–Online Mendelian Inheritance in Man disorder interactions, and unique experimentally validated information (e.g., cell lines, diseases, miRNA processing proteins). In this chapter, we describe a schematic workflow on how one can access the stored information from miRWalk and subsequently summarize its applications.