Interaction of cyanine dyes with nucleic acids. 2. Spectroscopic properties of methyleneoxy analogues of Thiazole Orange
1996; Institute of Molecular Biology and Genetics of NASU; Volume: 12; Issue: 6 Linguagem: Inglês
10.7124/bc.000458
ISSN1993-6842
AutoresS. M. Yarmoluk, Vladyslava Kovalska, T. V. Smirnova, Mykola P. Shandura, Yuriy P. Kovtun, G. Kh. Matsuka,
Tópico(s)Synthesis of Tetrazole Derivatives
ResumoA series of asymmetric cyanine dyes based on methylenoxy benzothiazole terminal heterocycle was synthesized. Absorption and fluorescent properties of these dyes and their complexes with nucleic acids were investigated. The best results were obtained with 2-[(3methyl-2( 3H )-benzothiazolyliden )-methyl ] -5,6-dioxymethylene-3-methylbenzothiaz olium p-toluenesulfonate (Cyan 13). A possible model of binding monomethyne benzthiazole cyanine dyes with double-stranded nucleic acids is proposed.
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