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Effect of Adrenotropic Hormone on Ascorbic Acid and Cholesterol Content of the Adrenal.

1944; SAGE Publishing; Volume: 55; Issue: 4 Linguagem: Inglês

10.3181/00379727-55-14537p

1535-3702

Gearóid Sayers, Marion A. Sayers, Harold L. Lewis, C. N. H. Long,

Hormonal Regulation and Hypertension

A single dose of pure adrenotropic hormone diminishes both the ascorbic acid and cholesterol content of the adrenals. The level of ascorbic acid is reduced to two-thirds within 20 minutes and one-half of its normal value in one hour. It has again returned to its initial concentration 9 hours after hormone administration. On the other hand the maximum decrease in cholesterol is not reached until 3 hours after injection and its restoration also occurs at a slower rate. It is suggested that the two processes may be related to cortical hormone synthesis in or release from the adrenal gland.