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Pathophysiology of Celiac Disease

2012; Elsevier BV; Volume: 22; Issue: 4 Linguagem: Inglês

10.1016/j.giec.2012.07.003

1558-1950

Sonia S. Kupfer, Bana Jabrì,

Digestive system and related health

Celiac disease results from the interplay of genetic, environmental, and immunologic factors. An understanding of the pathophysiology of celiac disease, in which the trigger (wheat, rye, and barley) is known, will undoubtedly reveal basic mechanisms that underlie other autoimmune diseases (eg, type 1 diabetes) that share many common pathogenic perturbations. This review describes seminal findings in each of the 3 domains of the pathogenesis of celiac disease, namely genetics, environmental triggers, and immune dysregulation, with a focus on newer areas of investigation such as non-HLA genetic variants, the intestinal microbiome, and the role of the innate immune system.