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Antibody-dependent adherence of guinea pig eosinophils to the third-stage larvae of Metastrongylus apri.

1986; Japanese Society of Veterinary Science; Volume: 48; Issue: 3 Linguagem: Inglês

10.1292/jvms1939.48.623

1881-1442

Osamu Sasaki, Masanori Katsuno,

Parasites and Host Interactions

The serum of guinea pigs infected with Metastrongylus apri (M. apri) promoted the adherence of peritoneal eosinophils, obtained from normal and infected animals, to the third-stage larvae in vitro. The promotion of eosinophil adherence was first detected in the serum 14 days after infection followed by marked increase in the activity as the infection progresses. In such sera, immunoglobulin G capable of reacting with the cuticular surface of the larvae was demonstrated. The antibody-dependent eosinophil adherence reduced the infectivity of the larvae, suggesting that eosinophils may play a protective role against M. apri in vivo.