The Use of Blood from Selected Chickens as an Immunizing Agent for Marek's Disease
1972; American Association of Avian Pathologists; Volume: 16; Issue: 1 Linguagem: Inglês
10.2307/1588909
ISSN1938-4351
AutoresD. V. Zander, Richard W. Hill, R. G. Raymond, R. K. Balch, Robert W. Mitchell, J. W. Dunsing,
Tópico(s)Mycobacterium research and diagnosis
ResumoA mild Marek's disease agent (CHV) found in the blood of otherwise specific-pathogen-free chickens provided a safe and effective protection against virulent Marek's disease. The mild MD agent was administered subcutaneously as a suspension of freshly drawn citrated blood and was effective whether all or only a small percentage of the flock were inoculated. Chickens were protected even when the virulent challenge virus was given as soon as 2 hours after immunization. When CHV was passed 25 times in cell culture, it was ineffective as a vaccine against MD. However, cell-culturepropagated turkey herpesvirus protected against disease when chickens were challenged with virulent MD virus. In field application, inoculation of only a small percentage of a flock with fresh blood from pathogen-free chickens which were infected with CHV would be expected to provide adequate protection only where the physical plant and management system preclude early exposure to virulent MD virus.
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