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Population variation of HLA genes in rural communities in Brazil, the Quilombos from the Vale do Ribeira, São Paulo – Brazil

2016; Elsevier BV; Volume: 77; Issue: 6 Linguagem: Inglês

10.1016/j.humimm.2016.04.007

1879-1166

Kelly Nunes, Bruno Zagonel Piovezan, Margareth Afonso Torres, Gerlândia N. Pontes, Lilian Kimura, Juliana Emilia Prior Carnavalli, Regina Célia Mingroni‐Netto, M. E. Moraes, Diogo Meyer,

HIV Research and Treatment

In the present study, we characterized the allelic and haplotypic profile of the genes HLA-A, -B, -C and -DRB1 (PCR-SBT) in a population sample of 144 highly admixed individuals, coming from rural communities in Brazil (Quilombos from Vale do Ribeira, in the State of São Paulo). Furthermore, we identified three individuals with a new null allele in the HLA-C gene (HLA-C(∗)02:105N), associated with the haplotype HLA-A(∗)80: 01∼B(∗)18: 01:01G∼DRB1(∗) 07:01.